The 3-dimensional structure of native antithrombin was first determined in 1994.

Some in the late stage also show increased antithrombin.

In some situations, infusion with antithrombin may be necessary.

In human adults, the normal blood level of antithrombin activity has been measured to be around 1.1 units/mL.

The genetically engineered offspring were bred for the presence of antithrombin in their milk.

Similarly, antithrombin can also spontaneously convert to the latent state as part of its normal function.

The human antithrombin is extracted from the goats' milk to make ATryn.

The conformational changes that occur within antithrombin in response to pentasaccharide binding are well documented.

Microinjection was used to insert human antithrombin genes into the cell nucleus of their embryos.

The diagnosis is made by checking for low levels of antithrombin III in the patient's blood.

That shortfall of antithrombin puts patients at risk of life-threatening blood clots.

A single glycosylation site remains consistently un-occupied in the minor form of antithrombin, β-antithrombin.

Important It is possible that the main title of the report Antithrombin Deficiency is not the name you expected.

Antithrombin deficiency may also be acquired; in such cases, the disorder may be reversible with treatment.

Thrombin is also inactivated by antithrombin, a serine protease inhibitor.

Atryn, which is given by infusion, is for people with a rare condition called hereditary antithrombin deficiency.

Current treatment involves taking blood thinners and getting infusions of human antithrombin, which is extracted from donated blood.

The potential glycosylation site at asparagine 135 is not occupied in a minor form (around 10%) of antithrombin, β-antithrombin (see Figure 1).

This is thought to be due to a requirement that antithrombin and thrombin must bind to the same heparin chain adjacent to each other.

Most cases of type I deficiency are due to point mutations, deletions or minor insertions within the antithrombin gene.

GTC states that one genetically modified goat can produce the same amount of antithrombin in a year as 90,000 blood donations.

For example, after injury to the blood vessel wall, heparin is exposed, and antithrombin is activated to control the clotting response.

Factor IX is inhibited by antithrombin.

Antithrombin (AT) is a small protein molecule that inactivates several enzymes of the coagulation system.

It is made from the milk of goats that have been genetically modified to produce human antithrombin, a plasma protein with anticoagulant properties.

Appalachian National Scenic Trail (shared by 14 states)

Details were not released, but officials said the deal would increase the buffer around what is officially called the Appalachian National Scenic Trail.

(CNN) -- The length of the Appalachian National Scenic Trail is constantly changing.

The Appalachian National Scenic Trail follows the crest of the mountain through Maryland and a portion of Pennsylvania.

Much of the mountain is protected as part of the viewshed and corridor of the Appalachian National Scenic Trail, which crosses the summit grounds.

At this point, the byway crosses the Appalachian National Scenic Trail and heads across South Mountain State Park.

Appalachian Trail (Appalachian National Scenic Trail in the eastern U.S.)

Besides a portion of the Appalachian National Scenic Trail, this is the only NPS site in New Hampshire.

The loop continues west on US 40, coming to Greenbrier State Park which has access to the Appalachian National Scenic Trail.

The proposed route very roughly parallels the Appalachian National Scenic Trail, but generally follows river valleys and utilizes many long-abandoned logging roads that criss-cross the region.

Appalachian Trail Work Crew Working as part of a volunteer crew to build and protect the Appalachian National Scenic Trail is a decidedly couch-free affair.

The battlefields are preserved within the South Mountain State Park, Gathland State Park, and the Appalachian National Scenic Trail.

He also made more than 60 additions to the system of National Parks, among them the Redwood National Park in California and the Appalachian National Scenic Trail.

The most famous American long trails are The Appalachian National Scenic Trail, generally known as the Appalachian Trail and the Pacific Crest Trail.

In addition, the Appalachian National Scenic Trail Foot Bridge, constructed in 2000 on the pilings of a former railroad bridge, crosses the reservoir about 0.5 mile upstream from the dam.

Mount Greylock has over 70 miles of designated trails for hiking, mountain biking, back-country skiing, snowshoeing and snowmobiling, including an 11.5 mile section of the Appalachian National Scenic Trail.

Areas in Vermont administered by the National Park Service include the Marsh-Billings-Rockefeller National Historical Park (in Woodstock) and the Appalachian National Scenic Trail.

The Appalachian National Scenic Trail is the nation's longest "marked footpath," stretching approximately 2,178 miles (the exact figure fluctuates) from the summit of Springer Mountain, Georgia to the top of Mt.

The Appalachian National Scenic Trail passes through this region, and the portion that passes through the region's Mahoosuc Notch is popularly considered by hikers to be the most difficult mile of the entire trail.

Areas maintained by the National Park Service include Appalachian National Scenic Trail, Quinebaug and Shetucket Rivers Valley National Heritage Corridor, and Weir Farm National Historic Site.

The National Park Service owns and maintains approximately 800 acres of land that has been acquired to protect the Appalachian National Scenic Trail in this area, which winds along the Blue Mountain ridge and through the associated gaps.

The route crosses the Delaware Water Gap National Recreation Area, the Middle Delaware National Scenic and Recreational River, and the Appalachian National Scenic Trail on the path of the existing power line.

The Appalachian National Scenic Trail, generally known as the Appalachian Trail or simply the A.T., is a marked hiking trail in the eastern United States extending between Springer Mountain in Georgia and Mount Katahdin in Maine.

Conservation groups condemned the administration’s decision to build the wider, $1.2 billion line, which slices through the Appalachian National Scenic Trail, the Middle Delaware National Scenic and Recreational River and the Delaware Water Gap National Recreation Area in Pennsylvania and New Jersey.

And the Appalachian trail crosses the eastern end of the park.

There were brown bears, she knew, nearby on the Appalachian trail.

Seventy miles of the Appalachian trail run along the park's top ridge.

The Appalachian Trail is less than half an hour away.

The Appalachian Trail runs up one side and down the other.

The lake is just a few miles from the Appalachian Trail.

Safety along the Appalachian Trail has never been a serious concern.

None of them, however, went so far as to impugn the Appalachian trail.

Walk it off on the Appalachian Trail, which is right outside the door.

His staff had said he was hiking the Appalachian Trail.

He first came up with the idea when hiking the Appalachian Trail in 1996.

The Appalachian Trail also crosses the town in the east.

Four miles of the Appalachian Trail run through the scenic area.

Interstate 84 and the Appalachian Trail pass across the town.

Efforts are under way to connect to the Appalachian Trail.

Also, the development would have been visible for miles along the Appalachian Trail.

While in prison he reads books about the Appalachian Trail.

Hike a bit higher and you'll find yourself on the Appalachian Trail.

Did anybody know you were planning the trip to the Appalachian Trail?

Also a small portion of the Appalachian Trail runs through the county.

The Appalachian Trail is located on the western edge of the area.

It was the first time a double murder had taken place on the Appalachian Trail.

But a group is trying to bridge the final 40-mile gap to the Appalachian Trail.

Go south past a church for two miles to a big sign marking the Appalachian Trail.

One leads to the Appalachian Trail, near the park's western border.

Here is a look at how things have gone so far.

At the end of a year, they brought him home.

What we really want to see is people going at one another.

I looked at the long hours as part of life.

I never thought money would come back at me because of my name.

Not everyone, of course, looks at the matter in the same way.

At other times, he seemed not to hear some questions.

About 11 percent of the students at the school are black.

At the end of 2005, his son left the company as well.

At 28, he is a young man who has something to say.

At home, our children came running out to see us.

Things were going pretty bad for us at the time.

She was 7 or 8 years old at the time.

She just turned up at the front door last summer.

We would just make up what he was when they asked at school.

Then looked at by only two or three other people?

The man wanted me to order the next course at the same time.

People did their best to let the work at hand get them through.

Officials at each place said they had no idea where he was.

The two work long hours, so they often get together late at night.

She can stay only for six months at a time and cannot work.

They can also come at any time of the year.

They then had the women report their state of health at 54.

But at some point they got to take care of themselves.

But at the same time, I got the job done.

She and her mother still talk on the phone several times a week.

They told her the building was back on the market.

One hit him on the right side of the head.

But we're doing a pretty good job on them now.

Some had been on the market for more than two years.

But on bad days, 4 or 5 people come in.

What we need is a second set of eyes on the field.

Many felt they had to call on him one last time.

But I could never go on the street and hit someone.

The man on the other end said he would come down.

But you can also do all these things on your own.

I, on the other hand, have thought of him nearly every day since.

Looking on the back of my bill is not much help.

We've been on our feet for four hours without a break.

What sort of book are you working on these days?

The voice on the other end said she had the wrong number.

So we started to talk on the phone a lot and became friends.

A change on the ground in Iraq is also needed.

Little did I know she would be using them on me.

Three years later, the company is still working on its answer.

They were best left on the side of the road.

I told her to just be still, help was on the way.

You may be on your feet a good long while.

By then I've been on my feet for more than six hours.

If you want the city view, take a table on the west side.

Here is a look at how things have gone so far.

At the end of a year, they brought him home.

What we really want to see is people going at one another.

I looked at the long hours as part of life.

I never thought money would come back at me because of my name.

Not everyone, of course, looks at the matter in the same way.

At other times, he seemed not to hear some questions.

About 11 percent of the students at the school are black.

At the end of 2005, his son left the company as well.

At 28, he is a young man who has something to say.

At home, our children came running out to see us.

Things were going pretty bad for us at the time.

She was 7 or 8 years old at the time.

She just turned up at the front door last summer.

We would just make up what he was when they asked at school.

Then looked at by only two or three other people?

The man wanted me to order the next course at the same time.

People did their best to let the work at hand get them through.

Officials at each place said they had no idea where he was.

The two work long hours, so they often get together late at night.

She can stay only for six months at a time and cannot work.

They can also come at any time of the year.

They then had the women report their state of health at 54.

But at some point they got to take care of themselves.

But at the same time, I got the job done.

So I ask you to sort of have at it this morning.

And if you want to lose your hair, just have at it.

Just tell this guy what you want and have at it.

This is the last go I have at it, she said.

Wait until you're really ready to go to sleep, then have at it.

"Why doesn't he ask everybody if they want a free car while he's at it?"

But this one is on you and Bill have at it just like rest of us that work for a living.

While he's at it, he would like to save the world.

So for the last time, have at it: no half measures.

Are you given a story framework and told to have at it?

Let the candidates have at it in their final debate.

She's at it all the time and it's get tin' me down.

I figure while she's at it, she might as well bring back the plants and the flowers.

But some of you are experts, so have at it in the comments.

If others want to do the same, have at it, and we can compare notes.

He'll probably drive me crazy while he's at it, Jack thought.

"We're essentially saying that where the commercial industry can provide what we need, have at it."

He had pictures taken by a photographer of them having at it in every possible way.

So I probably won’t be able to join in the comments section, but have at it.

Get a band, circle the wagons, and then just kind of have at it.

They shoved us in the ring and said have at it.

The fifth ship and one of the original four were really having at it.

And it's not just China, by any means - everybody's at it.

Oh, and why not forty days of rain while he's at it?

Look, if anybody still wants to dispute the science around climate change, have at it.

We have been at it for more than three years.

We are in good form and everyone is at it.

As everyone knows, they have been at it ever since.

She has been at it for almost half a century.

After all, he has been at it for 24 years.

Get some for the kids while you are at it!

Our research & development people have been at it again.

After a month or two, people will be at it again.

And she's been at it for more than a century.

Why not put them in schools while we're at it?

And help an old friend out while you're at it.

I don't care how much better you are at it.

While she was at it, a call came in to her.

And ask him a few questions while you're at it?

You've been at it for months now without a break.

Some have been at it for years. Others are just beginning.

Poor thing has been at it for better than three days.

I thought they were going to be at it all day.

He'd still be at it if he were out here.

And maybe do a little business while you're at it?

And bring us a couple more while you're at it.

And we've only been at it for a few hours.

Yet not one year later the same people were at it again.