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Gods, but he looks like his mother, the doctor thought with despair.

Never had he heard the man speak with such despair.

She turned her head, eyes filled with anger and despair.

For a moment he saw hope struggle with despair and pain.

Some were cause for hope, but others filled him with despair.

These children live with despair every day of their lives.

Sick with despair he felt his way back to the body and sat down.

We're not going to make it, he thought with despair.

They could have tried to make their peace with despair.

The heavy air seemed to load those up with despair.