A weaker but detectable binding to the SH3 domain of Grb2, however, was observed.
Exon bridging interactions may occur less efficiently as a result of weak binding of splice factors at the acceptor site, thus modulating the splicing efficiency.
The problem is that DNS creates a relatively weak link or, to use the fancy term, "binding," a weak binding between the domain name and the IP.
High [ATP] - inhibition, mediated by weak binding at a third site, which is relatively specific for the adenine nucleotides.
Note also that the weight matrix only captures the sequence dependent part of the binding energy, so 'weak' binding could equally well be termed 'nonspecific'.
In the absence of ATP, a very weak binding was observed whereas with increasing amount of ATP strong binding was detected.
Since each of the supposedly weak sites in tyr T DNA is adjacent to a much better site the weaker binding might be removed by this cooperative interaction.
Thus, the diminished expression of MMP-1 in IDO transfectants could explain their weaker binding to this substrate.
We can then test the prediction that multi-TAS regions bear either weak binding- or cut-sites.
Low K values mean strong binding or high affinity; high K values mean weak binding to the target or low affinity: