The main cause of treatment failure is due to not following the treatment plan.

This is a common pattern of treatment failure in melanoma.

The optimal therapy for patients with treatment failure has not been established.

No data are available to guide recommendations for the management of treatment failure.

Most treatment failures occur within the first 2 years following definitive therapy.

For both drug classes, the first reports of treatment failures came from Asia.

There are a number of reasons for treatment failure.

No data are available to guide recommendations for managing treatment failure.

Optimal management of patients with treatment failure is not known.

There are currently no recommendations for the management of treatment failure.