In single-minded effort, the duke smothered his offering over Mearn's smoldering horsecloths, unconcerned if he blistered his flesh.

And so she embarked on a single-minded effort that would earn her a nickname: the Interferon Queen.

"There's something really neat about putting a lot of effort, single-minded effort, into one pursuit."

It means little now, as I watch her, in a single-minded effort against the clouds recently troubling the horizon.

The Zanmi Lasante hospital serves about a million people and represents years of single-minded effort by Paul Farmer.

Their single-minded efforts to prevent racy material from Milwaukee's movie screens kept nearly all instances of nudity and sexual expression from the city for nearly a decade after it appeared elsewhere.

Hellman has pulled Memorial back from its single-minded efforts to remove tumors by heavy cutting.

The rebuilding was almost entirely the single-minded effort of Rafik Hariri, prime minister from 1992 to 1998; his enemies are now in power and cutting off his permits.

That we turned away from conflict to the path of partnership was due to the single-minded efforts of a small number of enlightened individuals dedicated to Franco-British rapprochement.

In the tape, Beers, dressed in a sweatshirt and shorts, seems baffled by Gross's single-minded effort to kill him.