The French Broad and Atlantic Railway was a railroad that served western South Carolina in the late 19th century.

The Bishopville Railroad was a shortline railroad that served central South Carolina in the late 19th century.

The Orangeburg Railroad was a shortline railroad that served central South Carolina in the early part of the 20th century.

The Due West Railway was a shortline railroad that served western South Carolina in the first half of the 20th century.

The Northeastern Railroad was a railroad that served South Carolina in the second half of the 19th century.

The Greenville and Columbia Railroad was a railroad that served South Carolina in the 19th century.

The Alcolu Railroad was a shortline railroad that served South Carolina in the early 20th century.

The Florence Railroad was a railroad company that served eastern South Carolina in the late 19th century.

The independent line served Western South Carolina until it was abandoned in 1941.

The Barnwell Railway was a shortline railroad that served western South Carolina in the late 19th century.