This will activate presynaptic L-AP4 receptors and reduce glutamate release.

The reason for this is due to the 4 to 5-fold increase in glutamate release which is released during the acute withdrawal state in between binges.

In contrast during withdrawal from chronic alcoholism only a 2 to 3 fold increase in glutamate release occurs.

The high levels of glutamate release causes a chain reaction in other neurotransmitter systems.

Excessive glutamate release is a known major cause of neuronal cell death.

Change in the probability of glutamate release.

They can also inhibit glutamate release and can modulate voltage-dependent calcium channels.

In addition, reduced glutamate release in the dorsal hippocampus has been linked to spatial memory loss.

It has anticonvulsant and neuroprotective effects, and reduces glutamate release.

Excessive glutamate release can lead to excitotoxicity causing cell death.