The increase in calcium will initiate more insulin release from each beta cell.
Diazoxide interferes with insulin release through its action on potassium channels.
As a consequence, insulin release from the pancreatic beta cells is increased.
When the glucose level comes down to the usual physiologic value, insulin release from the β-cells slows or stops.
Treatment with indomethacin (2 mg/kg) had no significant influence on insulin release.
Caffeine may cause a rise in blood sugar and this, by stimulating insulin release, may lead to fat deposition.
As for the first phase, insulin release is triggered rapidly when the blood glucose level is increased.
This allows for the formation of a subcutaneous depot that results in slow insulin release into the systemic circulation.
Some types of amino acids also stimulate insulin release.
They act by increasing insulin release from the beta cells in the pancreas.