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The studies should also help boost surveillance for similar changes in wild-type strains, and to develop diagnostics, drugs and vaccines.
These concentrations were compared with levels measured in mitochondria of the wild-type strain, bearing 100% intact mitochondrial genomes.
For genes not involved in deletion, equilibrium transcript concentrations were identical in the mutant and wild-type strains.
Microarray analysis of the actA time courses revealed that the host transcriptional responses were remarkably similar to those observed during infection with the wild-type strain.
Mutant and wild-type strains of Neurospora are available from the FGSC.
This is the opposite of a uracil prototroph, or in this case a wild-type strain, which can still grow in the absence of uracil.
These differences may be due to the relative increase in mitochondrial genomes in the mutant strain (mtDNA/nuclear DNA 1.5 compared with the wild-type strain).
The wild-type strain expresses the xylE gene product, catechol 2,3-dioxygenase, such that when its colonies are sprayed with catechol, they turn bright yellow, while wild-type colonies remain white.
Slr1 mutations in mice results in decreased filamentation and reduces damage to epithelial and endothelial cells that leads to extended survival rate compared to the Slr1 wild-type strains.
Like an alr1 mutant, growth of an mnr2 mutant was sensitive to Mg-deficient conditions, but the mnr2 mutant was observed to accumulate more Mg than a wild-type strain under these conditions.
This was not observable with transcripts isolated from the wild-type strain, nor with the cytochrome b or ND4 probes hybridized with transcripts from the mutant strain (Figures 4B and 5B).
The Pgm coding-region sequences were cloned and sequenced from the Pgm F, Pgm Mand Pgm Shomozygous strains and from the Canton-S wild-type strain.
As one might generally expect, making ZAP1 nonfunctional in a zinc-deficient environment creates a similar relative effect on most significantly differentially expressed genes to that created by providing zinc to a zinc-deficient wild-type strain (Figure 6d).
He was also instrumental in the sequencing of The first Sri Lankan Genome, analysis of the first Malaysian Genome and sequencing and analysis of the Wild-type strain of Zebrafish.
In 2009 he and his colleagues at the Institute of Genomics and Integrative Biology announced the sequencing of the wild-type strain of zebrafishand the sequencing of the first Human Genome from India.
The FGSC also holds a number of non-accessioned strains including the wild-type strain collection of Dr. David Perkins as well as Neurospora strains from a number of other researchers who have retired.
Recent work supported this model, by showing that Alr1 activity was increased in an mnr2 mutant strain, and that the mutation was associated with induction of Alr1 activity at a higher external Mg concentration than was observed for an Mnr2 wild-type strain.
To support this hypothesis, she performed an experiment in which she demonstrated that mutant strains of D. radiodurans which are highly susceptible to damage from ionizing radiation are also highly susceptible to damage from prolonged desiccation, while the wild-type strain is resistant to both.
These include new wild-type strains with higher activities against particular pests, transconjugant strains that combine the activities from more than one wild-type strain, including strains that are active against both Lepidoptera and Coleoptera, and genetically engineered bacteria in which a Bt toxin gene is expressed.