A light chain has two successive domains: one constant domain and one variable domain.

The paratope is shaped at the amino terminal end of the antibody monomer by the variable domains from the heavy and light chains.

The variable domain is also referred to as the F region and is the most important region for binding to antigens.

CDRs are supported within the variable domains by conserved framework regions.

As a consequence, any daughter B cells will acquire slight amino acid differences in the variable domains of their antibody chains.

The variable domain of syndecan-4 could be a site of self-association.

The variable domain of any heavy chain is composed of a single immunoglobulin domain.

In many cases, the functional being solved depends on the solution of a given partial differential equation defined on the variable domain.

The two variable domains bind the epitope on their specific antigens.

If parts of the variable domains are also replaced by human portions, humanized antibodies are obtained.