Extended usage of xylometazoline can result in decreased effectiveness or a build up of tolerance against the drug.

The required usage of cortisone over time resulted in him having Cushings syndrome.

Badawi went on to state that continued usage of crutches would eventually result in needing a wheelchair instead.

Sadly, the usage of kingfisher feathers resulted in the mass slaughter of many kingfisher species.

Overbroad usage has resulted in controversy, as purists state it has become a meaningless term.

As Maya would later explain, the Kiva power cannot be used by a normal human, as usage would ultimately result in death.

At power stations that are not equipped for removing sulfur dioxide, such usage of cooling towers could result in serious corrosion problems.

The dual usage of or confusion between metric and non-metric units has resulted in a number of serious incidents.

This unprecedented usage has resulted in eight lawsuits and numerous amendment proposals.

However, prolonged usage resulted in tolerance to the drug, requiring higher doses to reach the desired effect.