These markers indicate that a drug is working before ultimate proof of its effectiveness.

The new sequence is all of ours, ultimate proof that we're in this together.

"That would be the ultimate proof of your ability, wouldn't it?"

It will be the ultimate proof to those at the other end of the gate.

It is taken to be the ultimate proof of conjugal loyalty.

You still do not agree, although your unseen presence at my shoulder provides the ultimate proof that I am right?

But the Mars expedition had provided the ultimate proof that, plan as you liked, things went wrong.

Is this not the ultimate proof that the traditional model of development cooperation does not work?

Then came the ultimate proof that the Jets are bouncing back from defeat.

That, to me, is the ultimate proof of a life well lived.