De Jesús contracted an ulcer during the filming of Oriental Blood and died of ulcer complications on May 26, 1932.

Exploratory analysis identified prior slow healing, a large ulcer, multiple ulcers, and prior ulcer complications, in addition to smoking, as markers of slow healing.

The Food and Drug Administration said yesterday that Celebrex, a top-selling arthritis drug, must continue to carry a warning on its label that it can cause serious ulcer complications just as many other pain relievers can.

The study concluded that patients taking Celebrex suffered fewer serious ulcer complications than those taking ibuprofen or diclofenac.

The companies said that most patients who develop serious ulcer complications while taking other pain relievers do not have symptoms that would warn them that they are at risk.

Past history of ulcer recurrence or ulcer complications.

The F.D.A. said Celebrex, a top-selling arthritis drug from Pharmacia and Pfizer, must continue to carry a warning on its label that it can cause serious ulcer complications.

He continued performing in the Chicago area into the 1990s, and died from ulcer complications in 1999.

Guidelines for prevention of NSAID-related ulcer complications.

The F.D.A. estimates that 2 to 4 percent of all people who take pain relievers known as nonsteroidal anti-inflammatory drugs for a year experience serious ulcer complications.