If taken internally, toxic metabolites are produced as the oil is broken down in the liver and digestive tract.

Alternariol is a toxic metabolite of Alternaria fungi.

The toxic metabolites cause acidosis, a rise in the acidity of body fluids.

The toxic metabolites that have damaged that organ could affect others, as well.

The placenta allows free entry of ethanol and toxic metabolites like acetaldehyde into the fetal compartment.

Three times it managed to kill itself, with toxic metabolites twice, and then with a complete shutdown of electrical activity.

It is not uncommon to produce toxic metabolites (e.g. chloroform).

It is not entirely clear whether the fluoride itself is toxic-it may simply be a surrogate measure for some other toxic metabolite.

In these cases, it has been suggested that the toxic metabolite is produced more in the kidneys than in the liver.

Nortriptyline is associated with higher relapse due to its toxic metabolite.