A significant correlation between the amount of elastase production and tissue invasion was first discovered in 1984.

A negative serological result however can be equally important in excluding suspected tissue invasion by E. histolytica.

It is believed that the tissue degradation following plasminogen activation facilitates tissue invasion and, thus, contributes to metastasis.

There is frequently local tissue invasion and metastasis to the lungs.

Histological evidence of tissue invasion by hyphae with a positive culture for Aspergillus spp.

Once developed, the ulcer may become chronic and stable, but also it can run a destructive course with deep tissue invasion, osteitis, and risk of amputation.

Deep tissue invasion: Often with bone involvement, and potentially leading to amputation.

For example, tissue invasion and displacement to distant sites are normal properties of leukocytes; these steps are not needed in the development of leukemia.

Localized disease caused by Candida is characterized by limited tissue invasion to the skin or mucosa.

Its unique regulatory requirements at the cell surface have suggested a special role for MMP-2 in tissue invasion.