Much of Eisenberg's early work in the mid-1980s involved the use of tissue expansion for reconstructive surgery.

The surgeon may or may not deploy some sort of tissue expansion prior to the operation if there is insufficient skin tissue.

Patients with extensive hair loss may need two flaps in conjunction with scalp reduction and tissue expansion, he said.

Cortical destruction is a common finding with no soft tissue expansion in many cases.

Papaverine is also being investigated as a topical growth factor in tissue expansion with some success.

Those who use such a device employ the technique of tissue expansion, which causes new skin to grow.

Theoretically, there is no limit to the amount of tissue that can be created with tissue expansion, provided the process is conducted gradually.