tetrahydrofolic acid , THF (Abkürzung)

Folinic acid is a 5-formyl derivative of tetrahydrofolic acid.

Tetrahydrofolic acid, or tetrahydrofolate, is a folic acid derivative.

Trimethoprim acts by interfering with the action of bacterial dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid.

Tetrahydrofolic acid is needed for DNA and RNA synthesis in many species, including protozoa.

Dihydrofolic acid (dihydrofolate, vitamin B) is a folic acid derivative which is converted to tetrahydrofolic acid by dihydrofolate reductase.

Pyrimethamine interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR).

Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF).

This antagonistic effect is not due to the inhibition of dihydrofolate reductase, the enzyme responsible for the reduction of dihydrofolic acid to tetrahydrofolic acid, but rather to defective folate metabolism.

Folic acid, (tetrahydrofolic acid or the reduced form) in mega dosages of 80 mg/day is a competitive inhibitor that blocks the activity of XO (through XO's flavin active sites).

Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the intermediate Thymidine monophosphate (dTMP), precursor of DNA metabolite Thymidine triphosphate.

Folic acid in the study was prepared as tetrahydrofolic acid or the reduced form in 20 mg tablets, formulated with an equal amount of ascorbic acid for antioxidant purposes and for better absorption through the gut.

Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry.

Tetrahydrofolic acid is involved in the conversion of formiminoglutamic acid to glutamic acid; this may reduce the amount of histidine available for decarboxylation and protein synthesis, and hence the urinary histamine and formiminoglutamic acid may be decreased.

The simultaneous addition of sodium formate to such systems resulted in increased citrovorum factor activity in the cell-free supernatants (producing, as we know now, the 5-formyl derivative), and from this method of preparation of large amounts of the factor, its structure as levo-folinic acid (5-formyl tetrahydrofolic acid) was eventually deduced.