The high economic growth from 2000 to 2010 was regarded as substantial cause in poverty reduction and hunger eradication.

This was a substantial cause of his low spirits during much of 1936.

The child had been wounded in the original attack but the more substantial cause of death was her prematurity.

Father McGivney's early years gave him substantial cause to champion the underdog.

Pneumococcal disease is a substantial cause of illness and death.

Smith was convicted of manslaughter because the wound was the "operating and substantial cause of death".

The 1929-1932 bear market, which was a substantial cause of the Great Depression, saw a sharp drop of 89%.

The court also finds that the state's actions are a substantial cause of this constitutional violation.

In my opinion, the scientific evidence gained thus far about involuntary smoking is substantial and great cause for alarm.

No doubt it has been a substantial cause of the tremendous growth in volume since its inception.