somatic mutation

The most probable cause was a somatic mutation early in development.

This technique is important in the identification of the true somatic mutations.

These changes are called somatic mutations and are not inherited.

Cancer is the result of somatic mutations which provide cancer cells with a selective growth advantage.

Somatic mutation leading to mosaicism is prevalent in the beginning and end stages of human life.

This is a somatic mutation meaning it is not usually transmitted to descendants.

The somatic mutation theory of metastasis development has not been substantiated in human cancers.

However, somatic mutations tend to cluster in a limited number of signalling pathways, which are potential treatment targets.

His laboratory was also the first to demonstrate the rising frequencies, with age, of somatic mutations in human epithelial cells.

It has been estimated that the average tumor carries c.a. 80 somatic mutations, fewer than 15 of which are expected to be drivers.

Any somatic mutation in this cell can lead to hereditary transmission of that mutation.

Two genotypes were found in samples taken from the colony, but they are thought to have arisen through somatic mutation rather than sexual reproduction.

Schwannomas from one patient share the same constitutional mutations but have distinct somatic mutations.

This increase in homologous recombination leads to an increased somatic mutation frequency and genomic instability.

Many cancers are somatic mutations.

Somatic mutations are those that occur in non-germline cells that are not inherited by children.

The distinction between germline and somatic mutations is important in animals that have a dedicated germ line to produce reproductive cells.

Alternatively, four-leaf clovers could be caused by somatic mutation or a developmental error of environmental causes.

This mutation occurs after fertilization (postzygotic somatic mutation).

Somatic mutations are changes to the genetics of a multicellular organism which are not passed on to its offspring through the germline.

The children had a congenital germline mutation which was combined with an early lifetime somatic mutation to cause a tumour.

The spectrum of somatic mutations contributing to the pathogenesis of colorectal cancer is likely to be far more extensive than previously appreciated.

HRAS is a proto-oncogene in which somatic mutations in healthy people can contribute to cancer.

Only 2 known cases have been reported in males, one having a normal 46,XY karyotype, suggesting an early postzygotic somatic mutation.

There are over 1500 germline mutations and somatic mutations found in VHL disease.