This is a somatic mutation meaning it is not usually transmitted to descendants.
It has been estimated that the average tumor carries c.a. 80 somatic mutations, fewer than 15 of which are expected to be drivers.
However, somatic mutations tend to cluster in a limited number of signalling pathways, which are potential treatment targets.
The most probable cause was a somatic mutation early in development.
Two genotypes were found in samples taken from the colony, but they are thought to have arisen through somatic mutation rather than sexual reproduction.
Any somatic mutation in this cell can lead to hereditary transmission of that mutation.
These changes are called somatic mutations and are not inherited.
This technique is important in the identification of the true somatic mutations.
His laboratory was also the first to demonstrate the rising frequencies, with age, of somatic mutations in human epithelial cells.
Cancer is the result of somatic mutations which provide cancer cells with a selective growth advantage.