Histiocytomas usually occur as solitary lesions which undergo spontaneous regression.

A solitary lytic lesion of plasma cells is found on skeletal survey in an otherwise asymptomatic patient.

We have little reason to assume that the response of solitary lesions would be fundamentally different.

Those with solitary or multiple lesions without visceral involvement typically have a benign disease course.

If the measurable disease is restricted to a solitary lesion, its neoplastic nature should be confirmed by cytology/histology.

The typical thyroid adenoma is solitary, spherical and encapsulated lesion that is well demarcated from the surrounding parenchyma.

In the case of a solitary lesion or a questionable relationship to the primary tumor, a brain biopsy (usually a stereotactic biopsy) may be necessary.

Primary small cell gastric lymphomas are less frequent and are usually localised, solitary lesions that can be completely excised.

Glomus tumors are usually solitary and small lesions.

The most common adverse effect is pain, which is usually associated with solitary lesions.