Hyperinsulinemia has been shown to "play a role in obese hypertension by increasing renal sodium retention".
This results in sodium retention in the kidney, leading to water retention and increased blood volume.
The sodium retention leads to plasma volume expansion and elevated blood pressure.
Use of Novolog has also been associated with sodium retention and edema.
Nsaids also can cause sodium retention, raising blood pressure.
The last two are preferred due to less sodium retention and potassium wasting.
Hypertension develops due to this mechanism of sodium retention.
Liquorice is a plant to be respected: large doses in the wrong person can cause sodium retention and elevated blood pressure.
It should be noted that zinc is known to affect osmolality by increasing sodium retention.
The pattern of sodium retention under stress, Dr. Light found, runs in families that are more prone to hypertension.