It is used in people who are significantly overweight (obese) and have not been able to lose enough weight with diet and exercise alone.

If you're significantly overweight, losing weight can help cut down on the friction.

And to be sure, some people (rarely those significantly overweight) manage to shed 5 or even 10 pounds before the Fourth of July.

Being significantly overweight is linked to a wide range of health problems, including:

Like most diabetes sufferers, Blasko was significantly overweight at 5-foot-4, she weighed 260 pounds.

Still, obstetricians urge women who are significantly overweight to lose weight before becoming pregnant.

Losing pounds if you're significantly overweight can also help (less tissue to vibrate).

Yesterday, Bowe said he weighed 250 pounds, not really significantly overweight by his standards.

Despite greater awareness of exercise and more healthy foods, many Americans remain "significantly overweight," according to Federal researchers.

But the most dramatic benefits are seen in those who are significantly overweight.