But he acknowledged that the war in Iraq had taken a significant toll in public opinion.

Obviously, that did not take any significant toll on the Pirro campaign.

The assaults from the other ships do not appear to be taking a significant toll upon the larger vessel.

His father died around that time; the loss took a significant emotional toll on him, causing severe depression.

And it takes a significant toll on our pocketbooks, wasting billions in tax dollars every year.

But in the last 5 to 10 years research has shown that osteoporosis also takes a significant toll on men.

Unfortunately, the constant fight was taking a significant toll.

"Our operational difficulties during this quarter have taken a significant toll on our financial performance."

A long strike could take a significant toll on union and management.

Though incontinence is not dangerous, it can take a significant toll on emotional well-being.