The relationship between alcohol and breast cancer has been a subject of significant research.

Even so, there was no significant research done there until 1952.

There has also been significant research into the spirituality of older people.

His two areas of significant research were electricity and caloric theory.

Despite significant research, prognosis of this disease has changed little over time.

They also question whether he engaged in any significant research.

These claims, however, are not yet supported by significant clinical research.

Mount Evans has also been the site of significant research in the life sciences.

He also performed significant research in the field of electroretinography.

Taking another example, what happens when significant research and development is needed to adapt a commercial items for government use?