The procedure does not cause significant pain or any damage to the prostate.

The owners face significant pain and pressure because canceling the rest of the season would cost them so much in television revenue.

He's in significant pain, so we don't stay long.

The condition can cause significant pain with attacks that seem to have no specific cause.

She died three weeks and three days later, without significant pain, at home, surrounded by family.

However, on his first outing he again suffered significant pain and left the team.

When it does, it can cause significant pain and discomfort.

All her hair fell out and she endured significant pain, but the operation was successful.

Anyone with significant back pain - especially a woman who is near or over age 50 - should see a doctor.

Fibromyalgia patients can look the picture of health, despite their significant pain, and there's no specific known cause.