"We didn't suffer for 30 days to turn around and make a significant mistake."
In a day of 1,000 air sorties, there was at least one significant mistake.
These officials say that he has made some significant mistakes and that his approach may be stale.
It seems to me this guy has made one significant mistake after another.
The terrible irony was that the only significant mistake would come about if Scofield won.
In the example of a supermarket, buying the wrong product may not be a significant mistake.
Your analysis is good, but you made one very significant mistake.
Frazier was called upon to perform plays that would expose him to the most contact, and he did not make a significant mistake.
They are sometimes very significant mistakes, to the detriment of some of these countries.
Sadly, they didn't, and it was a significant Iranian mistake.