Family members said the scores showed significant impairments, along with dramatic fluctuations in his abilities from one moment to the next.

Men with symptoms of low testosterone can have significant impairment in quality of life.

The results were unambiguous: significant impairment in all areas tested.

We haven't been able to find very much in the way of significant impairment.

Analyses revealed significant impairments in patients' neurocognitive test performance on all measures.

The symptoms cause significant impairments or distresses in aspects of daily life.

There must also be clear evidence of clinically significant impairment in social, academic, or occupational functioning.

Article 138 outlaws Sexual exploitation of person with significant impairment.

"They will suffer a significant impairment of the face value of their paper."

He can carry on a conversation, they said, but has significant cognitive impairment.