No significant homology could be detected between the human and marsupial proteins outside this motif.

This method can be used as an ET surrogate if there is lack of significant homology between subclades of a protein family.

Other ORFs displayed no significant homology to known proteins.

By bioinformatics, this protein contains four predicted coiled-coil domains which has a significant homology to known transcription factors.

Clostridium perfringens beta toxin shows significant genetic homology with several other toxins.

Of the 240 novel genes, 92 have significant homology to known proteins, and the rest do not match any previously described proteins.

If a sequence has no significant homology found, homology modeling may not give reliable prediction in this case.

However, this kind of approach failed to work when a query protein did not have significant homology to the attribute-known proteins.

Regions with significant homology to the C2-domain have been found in many proteins.

When there is no significant homology found, protein threading can make a prediction based on the structure information.