This can lead to significant psychological distress for some caregivers.

Tobacco withdrawal has been shown to cause clinically significant distress.

Disclosure would likely cause the family significant emotional distress.

They become a problem that needs to be addressed when the conflicts that come from the expectations lead to significant distress.

Evidence of clinically significant distress or impairment in work or social life.

In addition, the depressive symptoms need to cause clinically significant distress or impairment.

It is estimated that 40% of infertile individuals experience significant emotional distress with possible long-term implications.

In some cases, patients may appear to be in significant distress.

Ongoing (chronic) insomnia lasts a month or more and can cause significant distress.

You or your partner are experiencing significant distress due to sexual dysfunction.