Well, if they had then that is certainly a most significant discovery.

Great scientists are sometimes remembered for their less significant discoveries.

By then, the scientists involved realized they had a significant discovery on their hands.

West End series was the most recent significant discovery,in 1983.

It's just that your goal is to seek out the most significant discoveries, to hit the high points.

Probably the most significant discovery is that the differences are very small and subtle.

Many of them established stock corporations in case they made more significant discoveries.

Each year there are probably four or five very significant discoveries.

The child had to make a "much more significant discovery.

It is hard to imagine a more significant scientific discovery.