"We have not found it a significant disadvantage to be outside Unesco."

The most significant disadvantage is the relatively low process yield with typical losses of 30%.

The most significant disadvantage is the high cost of the process.

For one community to do this puts small employers at a significant economic disadvantage.

However, he had flushed out a scheme to put the Federation at a significant disadvantage.

Housing condition also showed greater, but not significant, male disadvantage.

"This has turned out to be a significant competitive disadvantage."

There are significant disadvantages to relying on natural mushroom production.

"It puts women at a significant disadvantage, in a potentially violent situation."

I think it is going to be a significant competitive disadvantage for anybody who doesn't get there.