Tobacco was a significant business in Syracuse at the end of the 18th century.

No significant new business is coming to town to fill the gap.

Halliburton differs from many oil services companies in that it also does significant business with the federal government.

Partners with significant business became the equivalent of free agents in sports.

Many investors consider effects of global climate change a significant business and investment risk.

We see the chance to build a more significant business," he said.

But it should not blind us to the fact that some very real and significant businesses are being built here.

A. Very few of these companies have a significant international business.

Now, however, science fiction is becoming big business, culturally central, and even politically significant.

"This company could be a significant business in five years, but we can't wait until then to build the appropriate culture, human resources and processes."