We should all be hearing about significant breakthroughs later today.

When any research program, you could have a significant breakthrough.

What they discovered may be a significant medical breakthrough.

Few participants thought there would be a significant breakthrough in the talks, set to end today.

It was unable to make any significant breakthrough in the subsequent elections.

"Now we have to look at the implementation to see if, in practice, it is as significant a breakthrough."

However the party failed to make any significant political breakthrough.

A. I think we've had a number of significant breakthroughs.

Thanks to all these men and women, we have made a significant breakthrough: the compromise is a new text.

Unfortunately, the talks in Rio did not lead to a significant breakthrough.