The final stage involves destructive lesions of the skin and bones which can lead to severe disfigurement and disability.

He also had a sister, Violet, who suffered severe facial disfigurement.

It is benign, but without intervention it can result in severe disfigurement of the jaw.

De Lotbiniere's only child Henry, a son born in 1945, was a barrister, who suffered severe facial disfigurement caused by cancer.

People with severe disfigurements are automatically treated as if the disfigurement has a substantial adverse effect on day-to-day activities.

"We had a patient with a very severe disfigurement that would have been extremely difficult, if not impossible, to repair with classic surgery."

Pio Pico suffered from severe facial disfigurement that may have been due to acromegaly caused by a pituitary tumor.

Acromegaly is most commonly diagnosed in middle aged adults, and can result in severe disfigurement, serious complicating conditions, and early death if not treated.

He is said to have been wounded 17 times in his nation's service, resulting in his severe disfigurement and maiming.

This progression to noma is possible in malnourished susceptible individuals, with severe disfigurement possible.