Its action is mainly bacteriostatic, on highly sensitive strains it exerts a bactericide action.
Stable fluconazole resistance could be induced in vitro by subjecting sensitive strains to increasing concentrations of this antifungal.
On the basis of extensive experience with its use, chloroquine is considered the drug of choice for prophylaxis and treatment of sensitive strains of malaria in pregnancy.
Resistant strains were found to have an average mortality of 4.3% whereas 96.1% mortality was observed in a highly sensitive strain (Okamoto et al. 1993).
Further, the original naming is generally derived not from the sensitive strain the bacteriocin kills, but instead the organism that produces the bacteriocin.
Finally, it was found that mice having strains sensitive to pain were resistant to itch and vice versa.
Methyl and Bromine substiutions created an increase of pleconaril activity towards sensitive and resistant strains.
The upper limit is strain rate sensitive.
Amikacin can also be used to treat non tubercular mycobacterial infections and tuberculosis (if caused by sensitive strains) when first line drugs fail to control the infection.
Further hybrids from these ruderalis dominant strains were created using some of the more popular and standard photo-period sensitive strains.