Clinical and laboratory parameters (CD4 count and viral load) were monitored at each visit, and venous blood was collected for additional secondary outcomes during selected study visits.

The secondary outcome was change in the attribute scores at 28, 56, and 90 days after assignment to treatment or placebo.

For adverse events, the primary outcome sought was the proportion of patients experiencing any adverse event, with secondary outcomes of patients experiencing particular adverse events.

Those involved in the coaching program showed improvements in secondary outcomes such as weight loss, increased exercise, improved quality of life, less anxiety, and improvement in overall health and mood.

The secondary outcome was diastolic blood pressure.

The primary outcome was freedom from treatment failure after 16 weeks of therapy; the secondary outcome was attentional dysfunction.

Finally, the onset of action was considered as the primary outcome of the study while spontaneous recovery times and cardiovascular response as secondary outcomes.

Letters to the editor critiqued the definitions of secondary outcomes, questioned protocol changes, and expressed concern over generalisability of the results.

The secondary outcomes were also similar between groups.

A primary or secondary outcome used to judge the effectiveness of a treatment.