The activated receptor must first interact with other proteins inside the cell before the ultimate physiological effect of the ligand on the cell's behavior is produced.

It is possible that "cannabinoid receptors in our body interact with the cannabinoids in milk to stimulate a suckling response in newborns so as to prevent growth failure".

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell.

The receptor also interacts with activator protein 1 and Sp-1 to promote transcription, via several coactivators such as PELP-1.

These results further suggested that multiple opiate receptors (mu and kappa) interact to modulate itching behavior to chloroquine.

The receptors interact with VEGF and relay its message to the cells' central computing system in the nucleus.

This would suggest that the receptors interact extracellularly.

So, whenever a receptor interacts with an undigested antigen, the surface amino acids that come in contact may not be continuous with each other if the protein is unwound.

Only type I receptors have a heat shock protein (HSP) associated with the inactive receptor that will be released when the receptor interacts with the ligand.

The activated receptor interacts with the hormone response element and the transcription process is initiated as with type I receptors.