Therefore children with high pulmonary vascular resistance may not tolerate a Fontan procedure.
By blocking this interaction, bosentan decreases pulmonary vascular resistance.
It relaxes the arterial wall, leading to decreased pulmonary arterial resistance and pressure.
When the newborn takes its first breath, the lungs open and pulmonary vascular resistance decreases.
The dilution used was titrated for each animal to produce at least a 100% increase in pulmonary resistance.
This eventually leads to elevation of pulmonary vascular resistance and increased right ventricular afterload.
The pulmonary resistance is dramatically reduced ("pulmo" is from the Latin for "lung").
Once the baby is born, the lungs are needed for oxygen transfer and need high blood flow which is encouraged by low pulmonary vascular resistance.
Further, pulmonary vascular resistance usually drops back to close normal levels.
With the first breaths, there is a fall in pulmonary vascular resistance, and an increase in the surface area available for gas exchange.