IQGAP1 is now recognized as a protein scaffold that integrates signals regulating cell adhesion, actin cytoskeleton, the cell cycle, and other cellular functions.
They consist of a short variable peptide domain, attached at both ends to a protein scaffold.
Optimizing structural modeling for a specific protein scaffold: knottins or inhibitor cystine knots.
The Golgi matrix is a protein scaffold made up of golgins on the cytoplasmic side of the Golgi apparatus involved in keeping its shape and membrane stacking.
AChRs are localized opposite the presynaptic terminals by protein scaffolds at the postjunctional folds of the sarcolemma.
Other findings show connexins associate with protein scaffolds used in another junction, the zonula occludens ZO1.
This protein scaffold clearly provides a modular structure that is easily adapted to bind different substrates in proximity to bound ATP.
As with other antibody mimetics, the idea behind developing the Affibody molecule was to apply a combinatorial protein engineering approach on a small and robust protein scaffold.
Similarly, completely new functions can be selected for from existing protein scaffolds.
This forms into a protein scaffold onto which new enamel-forming calcium is deposited from the saliva.