prostacyclin

Information about the effect of diabetic control on prostacyclin production comes from animal studies.

However, no effects were seen on prostacyclin production acutely after the start of insulin treatment.

Similarly, prostacyclin production in human atherosclerotic tissue appears to be reduced.

It is obviously difficult to study arterial prostacyclin production in diabetic subjects.

If prostacyclin is inhibited by aspirin this beneficial effect is lost.

The drug, prostacyclin, eases breathing by dilating the hardened blood vessels.

Other novel medications that need to be inhaled or given intravenously include prostacyclin derivatives.

But aspirin also inhibits the production of prostacyclin in the cells that line the walls of blood vessels.

The loss of this source of prostacyclin could help explain why women who have had hysterectomies are prone to cardiovascular problems.

D'Angelo et al(1978) found no prostacyclin generation in atheromatous plaques from three subjects.

However, it is likely that this finding may indicate increased prostacyclin production in response to vascular injury (Dollery et al, 1983).

When these cells were incubated with serum from diabetic patients prostacyclin production was inhibited.

It has also been associated with decreased concentrations of 6-oxoprostaglandin F1a, a stable metabolite of prostacyclin.

Tranylcypromine-induced hypertension is not mediated by the inhibition of prostacyclin synthesis.

Differential sensitivity of regional vascular beds in the dog to low dose prostacyclin infusion.

Indeed Merck has stated that there was no effect on prostacyclin production in blood vessels in animal testing.

It is in homeostatic balance in the circulatory system with prostacyclin, a related compound.

Another of the new drugs, Remodulin, is a form of prostacyclin infused under the skin rather than through a catheter.

This work suggests that prostacyclin is not inactivated in the pulmonary circulation unlike other prostaglandins.

A few of these treatments include basic therapy, calcium-channel blockers, and prostacyclin therapy.

It does not stimulate as much prostacyclin and NO to induce relaxation on smooth muscle cells.

Effects of fish oil supplementation in the third trimester of pregnancy on prostacyclin and thromboxane production.

Thus a possible deleterious effect of hyperinsulinaemia may be the inhibition of prostacyclin production by arterial wall.

Iloprost is an synthetic prostacyclin.

Infusions of prostaglandins, e.g. prostacyclin, may be tried, with amputation in exceptionally severe cases.