prostacyclin synthase

By Prostacyclin synthase into prostacyclin (PGI2)

Prostacyclin is produced in endothelial cells from prostaglandin H (PGH) by the action of the enzyme prostacyclin synthase.

The series-3 prostaglandin PGH also follows the prostacyclin synthase pathway, yielding another prostacyclin, PGI.

Prostanoid precursor PGH2 diffuses from platelets to neighbouring synovium fibroblast expressing prostacyclin synthase which results in the formation of proinflammatory prostacyclin PGI2.

Other names in common use include prostacyclin synthase, prostacyclin synthetase, prostagladin I synthetase, PGI synthase, PGIS, PTGIS, and PGI synthetase.

Of special importance are the cytochrome P450 enzymes in animals, including CYP5A1 (thromboxane synthase), CYP8A1 (prostacyclin synthase), and the CYP74 family of hydroperoxide-metabolizing enzymes in plants, lower animals and bacteria.