While hope for change may be rising, opinion about the United States has never been as profoundly negative.

Coupled with deforestation, this had a profoundly negative effect on the landscape of Iceland.

His father's death in 1939 had a profoundly negative effect on his early life.

However, increased government intervention in domestic economy brought with it isolationist sentiment that had a profoundly negative effect on international economics.

"The weight of the evidence suggests that even small amounts of alcohol can have a profoundly negative effect on flight safety," the report said.

Therefore, something profoundly negative has happened to hitting in baseball, I mean, how else could you possibly read the evidence?

This would have profoundly negative implications in the Arab world for years to come.

Asmara's poor relations with neighboring countries have had a profoundly negative impact on the economy.

However, others have found that life satisfaction is compatible with profoundly negative emotional states like depression (Carson 1981).

The impact on Syria itself was profoundly negative.