But each little nuance of my role takes on profound significance.

Something of profound and lasting significance to the future of my City.

It would be an advance of profound cultural and economic significance.

After studying your articles I am deeply impressed with the profound significance of the whole matter.

And there is a philosophical difference of profound potential significance.

The novel deals in its more profound significance with the order of things.

You know you're already being ticketed for future flights, ones of profound significance.

And, for at least two of their number, the journey had taken on profound spiritual significance.

He states "upon really close examination, there are certain rather obscure features in the picture which have a profound significance."

Wheat fields became another subject of profound and metaphorical significance to him.