As he did, a sense of profound sadness settled over him.

She looked up at him, then nodded, a profound sadness in her face.

That she would no longer do so brought a profound sadness.

At the same time, women seem to experience a more profound sadness than do men.

But beyond that, a profound sadness made her keep fighting back tears.

There was no anger in his expression, just profound sadness.

We share the profound sadness for the nearly 3,000 lives that were lost.

After a moment she looked up at him, the disgust in her eyes touched with a profound sadness.

Yet the book left its readers with a profound sadness.

I had an attack of profound sadness at that point.