A look of profound regret passed over his face.

And he has expressed profound regret for that conduct.

History will look back on this science denial with profound regret.

I felt a mixture of relief - and profound regret.

And for all those things, I have profound regret.

Once again she felt profound regret that Gavin's wife had died.

Kirk got a sense of profound regret from the Master.

His grief had run itself out now and had been replaced with only a profound regret.

It was with the most profound regret that our forces accomplished this demonstration.

But having said that, I would have very profound regrets.