He felt like a fool, and at the same time was overcome by a sense of profound loss.

For that failure the Community has already suffered a profound loss of public faith.

This was a profound loss to the country and to letters.

She was a friend to all of us, and we feel a profound loss.

Four patients with profound loss of recognition participated in the study.

The pain of profound loss may never go away completely.

Marilyn felt a profound loss at having never known a father.

But 2003 began instead on a note of sudden and profound loss.

This year saw profound losses to the world of art.

We mourn this profound loss to his family and the entire community.