In "Watch Out," an Asian immigrant starves herself because of a profound cultural loneliness.

Mr. Morse never forgets that beneath the camp there are pain and profound loneliness.

The larger possibility, that plugging into our social networks might somehow remedy a profound national loneliness, is even more enticing.

The roots of Theo's isolation gradually emerge, but fail to make his utter loneliness more explicable or less profound.

Even with this many people standing together, each was touched by profound loneliness, and stood withdrawn in introspection and prayer.

This means that people who have gender identity disorder can experience profound loneliness.

She was aware of a deep and profound loneliness, a sense of isolation more acute than any she had felt before in her life.

So when the mysterious and handsome Simon comes along with a more profound loneliness a tentative friendship is formed.

The image reflects Manet's loss of hope about the military situation, his profound loneliness, and the deprivation he suffered during this time.

Nicole had also begun to experience a profound loneliness.