The inmates said they were subjected to profound isolation, cells encrusted with fecal matter, urine and food, and malfunctioning toilets.

They're quixotic in the truest sense, born of profound emotional isolation.

Between the death of his mother and his father's benign neglect, Tony grows up in profound isolation, a state he will not notice until he falls in love.

What's harder for Hubbell is his profound social isolation.

And they live in such profound isolation that one man wonders how many days' walk it is to Europe, having no idea that he lives on an island.

"Robinson Crusoe" was the great early document of radical individualism, the story of an ordinary person's practical and psychic survival in profound isolation.

Perversely, then, the prisoners who can't handle profound isolation are the ones who are forced to remain in it.

It was the light touch of a small hand on the hilt of his sword that startled him out of that profound isolation.

The Bechdels lived in this museum in a state of profound isolation.

Its spaciousness, extended indefinitely by an effect of obscurity, rendered more sensible his profound isolation.