In Philly in the late 70s and 80s, the teachers ruthlessly struck for weeks and weeks, which caused profound disruptions across the City.

Although modifications of the immune response occur in HIV-infected patients at all stages, opportunistic infections only affect those with profound disruption of their cellular immunity.

But then you come to those more profound disruptions in the historical record - the abrupt gaps in the narrative caused by the absence of Lucas's influence.

The marriage led to a permanent rift between Prem Rawat and his mother, and was also credited with causing a profound disruption in the movement.

By requiring that the procedures and the drugs create a profound disruption, the statue requires more than that the acts "forcibly separate" or "rend" the senses or personality.

The authors say they cannot find a definition of profound mental disruption in mental health literature or United States law, so they offer some examples of their own.

The Western premies remained loyal to Rawat but the marriage led to a permanent rift within the family and was also credited with causing a profound disruption in the movement.

The large berm immediately outside the wall and its dry moat led to a profound disruption and complication of the synergistic relationship between Paris and its suburbs.

No one would suggest that Seventh Avenue escaped the profound disruptions that followed Sept. 11.

It is Thanksgiving 1973, and even this film's sheltered suburb is on the brink of profound disruption.